

Exercise caution when co-administering LYRICA and thiazolidinedione antidiabetic agents.

Withdraw LYRICA gradually over a minimum of 1 week. Increased seizure frequency or other adverse reactions may occur if LYRICA is rapidly discontinued.LYRICA may cause dizziness and somnolence and impair patients' ability to drive or operate machinery.Monitor patients and adjust dosage as appropriate. Respiratory depression: May occur with LYRICA, when used with concomitant CNS depressants or in the setting of underlying respiratory impairment.Antiepileptic drugs, including LYRICA, increase the risk of suicidal thoughts or behavior.Discontinue LYRICA immediately in these patients. Hypersensitivity reactions (e.g., hives, dyspnea, and wheezing) can occur.Discontinue LYRICA immediately in these cases. Angioedema (e.g., swelling of the throat, head and neck) can occur, and may be associated with life-threatening respiratory compromise requiring emergency treatment.

